The NSF Division of Molecular and Cellular Biosciences in the Directorate for Biological
Sciences and Division of Physics in the Directorate for Mathematical and Physical Sciences (NSF/MCB and NSF/PHY) recently released Dear Colleague Letter (DCL) “ANR – NSF/Physics/MCB Lead Agency Opportunity at the Physics – Molecular and Cellular Biosciences Interface” (NSF 21-120). This DCL announces the continued collaboration between the French Agence Nationale de la Recherche (ANR) and NSF to support projects that use multidisciplinary approaches to examine mechanisms underlying essential life processes at the molecular, subcellular, and cellular scales. Proposals that use physics based experimental and theoretical approaches are encouraged.
Under the lead agency agreement, researchers can submit a single collaborative proposal that will go through a streamlined review process either at NSF or at ANR. In FY 2022 (October 2021-September 2022), NSF will serve as the lead agency for all proposals. Proposals should be submitted to: NSF 21-593 Division of Physics: Investigator Initiated Research Projects. The deadline for proposals is December 14, 2021. While proposals are submitted to NSF/PHY, they will be jointly reviewed by PHY and MCB.
Simultaneously, the French institution must submit a proposal with the identical Project Description, with any required additional information to ANR, via the ANR submission system (https://anr.fr/fr/appels/). The deadline for this is December 15, 2021.
For full details on submission guidelines, program priorities, and contact information, see the DCL: NSF 21-120.
The National Science Foundation (NSF) recently released a new solicitation (NSF 21-615) topic as part of its FY22 Emerging Frontiers in Research and Innovation (EFRI) Program, entitled, Engineering Living Systems (ELiS).
The Emerging Frontiers and Multidisciplinary Activities (EFMA) Office will host an informational webinar on October 15, 2021, at 2 PM EDT, to discuss the EFRI program and answer questions about the FY 2022/23 solicitation. To register for this webinar, go to this link.
The EFRI-ELiS topic will support transdisciplinary research to advance the design, modeling, fabrication, and manufacturing of engineered living systems to address societal needs as well as the associated ethical, legal, and social implications of using living systems as building blocks and components for next-generation sustainable engineering. More specifically, ELiS will seed and catalyze transformative and convergence research with the goal of creating living systems for sustainable engineering with a focus on three national/societal needs: Thread 1) a sustainable built environment, Thread 2) monitoring and surveillance for a safe built environment, and Thread 3) biomining for sustainable metal extraction and resource recovery. ELiS will also contribute to the development of the basic science and engineering knowledge needed to advance the respective missions of our Federal Partner Agencies including 1) NASA’s goals for sustainable space exploration and 2) the Defense Threat Reduction Agency (DTRA)’s goals for the development and deployment of enabling capabilities to understand the built environment, threats, and vulnerabilities.
Each proposal submitted in response to this topic of the EFRI solicitation is required to address one of the three research threads and each of the foundational research components listed below:
Foundational Research: 1) design and/or modeling, 2) fabrication and/or manufacturing, and 3) ethical, legal, and social implications.
Research Thread 1: Sustainable Built Environment
Research Thread 2: Monitoring and Surveillance for a Safe Built Environment
Research Thread 3: Biomining for Sustainable Metal Extraction and Resource Recovery
The full solicitation (21-615) can be found here. Letter of Intent will be due on November 10, 2021. Preliminary Proposal will be due on December 16, 2021. Full Proposal will be due on March 10, 2022.
Under the lead agency agreement, researchers can submit a single collaborative proposal that will go through a streamlined review process either at NSF or at UKRI, on behalf of both NSF/BIO and UKRI/BBSRC.
Potential proposers should submit a letter of Intention to Submit (ITS) by September 22, 2021. If both agencies agree that the research topic fits the topical areas identified for FY 2022, researchers will be invited to submit a full proposal to the appropriate NSF or UKRI program.
Projects must address the priorities of both UKRI/BBSRC and participating NSF/BIO Divisions. Proposers must provide a clear rationale as to the need of the US-UK collaboration, including the unique expertise and collaboration that the team will bring to the project.
For full details on submission guidelines, program priorities, and contact information, see DCL NSF 21-100.
BLOG ANNOUCEMENT:The MCB Blog members will be going on a hiatus until mid-August. We hope to see you again in the fall!
A new Dear Colleague Letter (DCL) was issued by the Directorate for Biological Sciences (BIO) on the development of new tools and methods to advance our understanding of cells. Tool Development for Cell Biology, or Tools4Cells (NSF 21-057), seeks to expand our knowledge of cells using interdisciplinary approaches that can leverage advances in other fields and apply them to cell biology. Some examples of these advances include gene-editing technologies such as CRISPR/Cas9 applied to probe gene localization, and the application of cryo-EM and x-ray free electron lasers to the study of protein structure and dynamics.
Read more about the DCL criteria and proposal submission details here.
The Division of Integrative Organismal Systems (IOS), together with the Divisions of Biological Infrastructure (DBI), Environmental Biology (DEB), and Molecular and Cellular Biosciences (MCB) in the Directorate for Biological Sciences (BIO) at the National Science Foundation (NSF) and the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) will host a webinar about the Enabling Discovery through GEnomics (EDGE) program, which recently released a new solicitation, (NSF 21-546). Following a brief presentation, program directors from all of the Divisions and agencies will be available to answer questions from participants.
Through the EDGE program, the NSF and the NIH support genomic research that addresses the mechanistic basis of complex traits in diverse organisms within the context (environmental, developmental, social, and/or genomic) in which they function. The program also continues to support the development of innovative tools, technologies, resources, and infrastructure that advance biological research focused on the identification of the causal mechanisms connecting genes and phenotypes.
Information on how to join the webinar live can be found below. The slides and transcript of the webinar will be posted here on the IOS blog as well as the EDGE program website after the live event.
The National Science Foundation (NSF) has established an agreement on research cooperation with the French Agence Nationale de la Recherche (ANR). The Dear Colleague Letter, titled, “NSF/Physics/MCB Lead Agency Opportunity at the Physics – Molecular and Cellular Biosciences Interface” (NSF 20-120), encourages collaboration between the U.S. and French research communities.
Two NSF divisions – the Division of Molecular and Cellular Biosciences (MCB) and the Division of Physics (PHY) – are participating in this collaboration. Proposals must address the research priorities of each of the participating entities: ANR, MCB, and PHY. Proposals that use multidisciplinary approaches that emphasize quantitative, predictive and theory driven science aimed at understanding mechanisms underlying essential life processes at the molecular, subcellular and cellular scales are sought. Priority will be given to proposals that leverage unique resources and capabilities of partners in the U.S. and France.
A registration file (dossier) must be submitted by December 1, 2020. For full details on submission guidelines, program priorities, and contact information, see DCL NSF 20-120.
Titled “UKRI/BBSRC-NSF/BIO Lead Agency Opportunity in Biological Informatics, Microbes and the Host Immune System, Quantum Biology and Synthetic Cell,” the DCL describes four new topical areas associated with the lead agency opportunity. The lead agency scheme allows for reciprocal acceptance of peer review through unsolicited mechanisms and helps reduce some of the current barriers to international collaborations.
There is a two-part application process: a letter of Intention to Submit (due October 21, 2020) will be reviewed for project eligibility. Eligible proposals will then be invited to submit to the appropriate lead agency program. Refer to the DCL for important details.
Projects must be a collaboration between at least one investigator in the US and one in the UK, must address the priorities of both UKRI/BBSRC and appropriate NSF/BIO divisions, and must address the topical areas identified in the DCL. Additionally, proposers must provide a clear rationale for the need for a US-UK collaboration, including the unique expertise and synergy that the collaborating groups will bring to the project.
For full details on submission guidelines, program priorities, and contact information, see DCL NSF 20-118. Please also see this NSF announcement about the collaboration.
Learn more about the Faculty Early Career Development Program (CAREER) solicitation (NSF 20-525) in an upcoming webinar on May 13. The webinar will provide a briefing on the CAREER program and solicitation requirements along with a Q&A session. Read about significant changes to the solicitation in MCB’s previous blog post. Registration is required for the webinar, view details about registration here. Submit questions to firstname.lastname@example.org.
BIO is excited to announce to the biological sciences community two new funding opportunities under the Understanding the Rules of Life (URoL) Big Idea: 1) Epigenetics and 2) Microbiome Theory and Mechanisms (MTM). The URoL Big Idea seeks to create a new paradigm at the convergence of science, engineering, and technology that will elucidate theoretical frameworks (rules) to enable prediction of the diversity of evolutionary solutions that biological systems use to support life processes seen across the planet. The National Science Foundation has recently invested $36 million in the first projects under the URoL portfolio from two separate solicitations and across more than thirty institutions.
The Epigenetics and MTM opportunities represent a collaboration across Directorates and Offices within the National Science Foundation. Specifically, Epigenetics intends to enable innovative research and promote multidisciplinary education and workforce training in the broad area of epigenetics, while MTM aims to understand and establish theory and mechanisms that govern the structure and function of microbiomes.
Integrative perspectives and research approaches from more than one research discipline are welcomed, as this is a cross-Directorate effort. The interdisciplinary scope of both programs aims to provide unique training and outreach opportunities to train the next generation of scientists in a diversity of scientific approaches and to engage society more generally.
Both programs offer two submission tracks:
Track 1 – for projects with a total budget of up to $500,000 and an award duration of up to 3 years, and
Track 2 – for projects with a total budget of up to $3,000,000 and award duration of up to 5 years.
Funding is now
available through the Semiconductor Synthetic Biology for Information Storage
and Retrieval Technologies (SemiSynBio-II) solicitation (NSF
20-518) which seeks to leverage synthetic biology
tools, concepts, and methodologies to advance the development of
next-generation semiconductor information storage and retrieval technologies that are driven by biological principles
and use biomaterials in the fabrication of storage and retrieval devices and systems.
goal of the SemiSynBio-II research program will be to foster high-risk/high-reward, multi-disciplinary,
longer-term basic research leading to novel high-payoff solutions for the
information-storage and retrieval industries based on recent progress in
synthetic biology and the know-how of the semiconductor technology.
aims to seed and foster collaborations among the researchers in physics,
chemistry, biology, materials science, computer science, and engineering
disciplines to develop new cross-disciplinary projects and curricula that will
model and integrate concepts, tools and methodology.
solicitation builds from the previous SemiSynBio solicitation (NSF
17-557, no longer active) to include aspects of data retrieval. Proposals
can be submitted during the submission window (due by 5 p.m. submitter’s local
time): February 14, 2020 – March 16,
2020. Full program details including program priorities, submission
guidelines, and contact information can be found in the full solicitation NSF 20-518.