Funding Opportunity

MCB ANNOUNCES A FUNDING OPPORTUNITY FOR BUILDING SYNTHETIC MICROBIAL COMMUNITIES FOR BIOLOGY

In recent years, researchers have assembled synthetic microbial communities that have novel compositions, genetics, and phenotypes, and they have used these communities to address both fundamental biological questions and a range of societal problems. To support such research efforts, NSF has released the Building Synthetic Microbial Communities for Biology, Mitigating Climate Change, Sustainability and Biotechnology (Synthetic Communities) solicitation (NSF 22-607).

The goal of this solicitation is to support research that addresses one or more of the three themes:

  1. Define the underlying mechanisms or rules that drive the formation, maintenance, or evolution of synthetic microbial communities
  2. Use synthetic microbial communities to address fundamental biological questions, including questions in molecular biology, cellular/organismal biology, ecology, and evolution
  3. Build synthetic communities with biotechnology, bioeconomy, or environmental engineering applications

Full Proposal Deadlines: October 03, 2022 (due by 5 p.m. submitter’s local time)

Anticipated Funding Amount: $9,500,000

To learn more, read the solicitation posted here and reach out to any of the cognizant Program Officers below.

Anthony Garzaaggarza@nsf.gov(703) 292-8440BIO/MCB
John McDowelljmcdowel@nsf.gov(703) 292-8008BIO/IOS
Andrea Porras-Alfaroaporrasa@nsf.gov(703) 292-2944BIO/DEB
Mamta Rawatmrawat@nsf.gov(703) 292-7265BIO/IOS

MCB ANNOUNCES COMPETITION FOR A NEW SYNTHESIS CENTER FOR MOLECULAR AND CELLULAR SCIENCES

In recent decades, the biological sciences have experienced an unprecedented growth in data as a result of new experimental technologies, advances in computational power, and big data approaches to research. There are, however, many barriers to making full use of available datasets.

Credit: Nicolle Rager, National Science Foundation

To unlock the full potential of existing data, NSF seeks to establish a Synthesis Center for Molecular and Cellular Sciences (SCMCS) (NSF 22-608) that will create new knowledge through innovative synthesis and integration of available data and related information. The Center should advance our ability to explain and predict how biomolecular structures, interactions, organization, and functions lead to dynamic cellular phenotypes, by focusing on complex questions and using contemporary approaches that are data-intensive, team-based, and promote open science. The Center will not directly support generation of new data, nor fund an individual research group, but rather will be dedicated to facilitating synthesis of available data by multidisciplinary research teams.

The Center must:

  • Address a compelling set of scientific questions in molecular and cellular biosciences that require or are ripe for breakthroughs from synthesis of available data.
  • Enable synthesis research, i.e., integration of diverse theories, methods, and data, bringing together cross-disciplinary expertise to advance mechanistic and predictive understanding of molecular and cellular systems.
  • Develop or provide the necessary resources to enable data management and integration, advance open science strategies, enhance access to existing infrastructure, foster collaboration and team science, and promote standards and best practices for synthesis research.
  • Build an effective and evidence-based training enterprise for the next generation of scientists.
  • Integrate efforts to broaden participation across demographic, geographic, institutional, and disciplinary lines in all activities.

Program Timeline:

  • SCMCS Program Webinar: September 15, 2022
  • Preliminary proposals due: January 13, 2023
  • Results of preliminary proposal review communicated to proposers: March 2023
  • Full proposals due: July 07, 2023
  • Reverse Site Visit (RSV) notifications and scheduling: November 2023
  • Declined proposers informed, and recommended awards announced: January 2024
  • Anticipated start date of awards: February 15, 2024

Anticipated Funding Amount: $20,000,000

To learn more, read the solicitation posted here and reach out to an MCB program director.

NSF will hold an informational webinar on September 15, 2022. Registration information for this webinar is posted on the Program Web page. The SCMCS funding opportunity will also be discussed in upcoming MCB Virtual Office Hours.

DEAR COLLEAGUE LETTER: NSF REGIONAL INNOVATION ENGINES (RIE) PROGRAM

The National Science Foundation’s (NSF) newly established Directorate for Technology, Innovation, and Partnerships (TIP) has announced the NSF Regional Innovation Engines (NSF Engines) program. This bold new initiative aims to significantly expanding our Nation’s innovation capacity by investing in key areas of national interest and economic promise, in every region of the United States. To accomplish this ambitious goal, the program will fund the development of Regional Innovation Engines that will cultivate and sustain activities in use-inspired research and development, translation of innovation to practice, entrepreneurship, partnership and stakeholder development, and workforce development to realize thriving regional innovation ecosystems. The outcomes of this program will enhance the nation’s economic and industrial competitiveness as well as national security.

The NSF Engines program provides up to ten years of funding per Engine award with a maximum budget of $160M, with up to an additional two years of funding to support development activities before creating an Engine. The program solicits proposals corresponding to three award types, as outlined below.

  • Type-1 awards are development awards that provide seed funding to enable awardees to lay the groundwork for establishing a new NSF Engine, with the goal of catalyzing a new innovation ecosystem for a specific topic area. Type-1 awards are intended to allow teams to prepare for the submission of a successful Type-2 proposal. The duration of a Type-1 award is up to 24 months, with a maximum proposed budget of $1M.
  • Type-2 awards are intended to support awardees representing a geographical region of service that are well-primed to support a regional innovation ecosystem. Type-2 awards provide funding for up to 10 years, with a total maximum budget of $160M.

Submission of a Type-1 development proposal is not required for the submission of Type-2 proposal. See the NSF Engines Broad Agency Announcement (BAA) for further details on the award types and the differences between the various types.

The BAA specifies proposal deadlines for both proposal types. Prior to submission of proposals, teams are required to submit a Concept Outline, which is due June 30, 2022, for both proposal types. Approval of a Concept Outline from a cognizant NSF Program Officer is required to submit a full proposal.

For more information about the NSF Engines program including frequently asked questions and upcoming webinars, visit the NSF Engines program website. Additionally, visit the NSF Engines BAA website to view proposal deadlines and information on award types and differences.   See MCB’s Blog Post from May 10 to learn more about NSF sponsored Bioeconomy Workshops that address critical national needs relevant to Engines.

NSF/BIO AND CHE WILL FUND ACQUISITION OF HELIUM RECOVERY SYSTEMS

NSF recognizes the concerns in the research community associated with the national and global helium shortage and the impact on critical research infrastructure such as advanced nuclear magnetic resonance (NMR) spectroscopy systems and other instruments with cooled magnets.  In response, the Directorate of Biological Sciences (BIO) and the Division of Chemistry (CHE) in the Directorate of Mathematical and Physical Sciences (MPS) announce their willingness to support the acquisition of helium recovery systems via the NSF Options to Address Helium Supply Shortage Concerns DCL. Given the limited availability of funds, priority for the support will be given to:

  • Existing NSF/BIO or NSF/MPS/CHE investigators
  • Shared use, multi-user, or core-lab academic facilities
  • Applications from under resourced institutions

Specific submission instructions for NSF/BIO and for NSF/MPS/CHE are contained within the DCL.  For BIO proposers, proposals are accepted at any time.  For CHE proposers, proposals should be submitted during the October 1 to October 31, 2022 submission window.

Special Office Hour addressing Helium Recovery Opportunities

In response to substantial early interest, we have scheduled a Special Virtual Office Hour webinar from 4-5 PM (EDT) on Friday, June 10, to provide a quick briefing from program staff in both Divisions, followed by extensive Q&A to help community members prepare for and take advantage of this opportunity.  Anyone planning to pursue this funding opportunity is urged to participate in the webinar by registering here. After registering, you will receive a confirmation email containing information about joining the meeting. For those unable to attend, slides will be posted on our CHE Office Hour website: https://www.nsf.gov/news/news_summ.jsp?cntn_id=300572&org=CHE

Attendees requiring closed captioning should contact the Chemistry division at ncarey@nsf.gov at least 48 hours in advance to ensure that this service is available.

MCB ANNOUNCES THE SECOND VERSION OF SENTINELS: DREAM SENTINELS

MCB has replaced the Dear Colleague Letter (DCL), Sentinel Cells for the Surveillance and Response to Emergent Infectious Diseases (NSF 20-105) with a new DCL:  

Sentinel Systems that Detect, Recognize, Actuate, and Mitigate Emergent Biological Threats (DREAM Sentinels).

In this new Sentinels DCL, MCB again partners with the Directorate for Engineering’s Division of Chemical, Bioengineering, Environmental and Transport Systems to call for proposals to be submitted to core programs that address novel synthetic biology approaches to quickly sense and respond to the next emergent biological threat prior to its evolution in its host or transmission to human populations.

All proposals submitted in response to this DCL should include biosensing and bioactuation elements that address a biological threat. The biosensing element should leverage the power of modern biotechnology and deliver robust and specific recognition of the biological threat. The results of bioactuation should alert the user, destroy the threat, protect the host, or initiate an immune response or other strategies that would mitigate the threat. Other possible areas of interest are included in the DCL.

Proposals submitted in response to this DCL should have a title prefaced with “DREAM Sentinels:”. Proposals should be submitted to the Systems and Synthetic Biology cluster where proposals are accepted without deadline and are reviewed as they are received.

Investigators interested in submitting a proposal are strongly encouraged to contact Anthony Garza, aggarza@nsf.gov. More information on the DCL can be found here.

It is anticipated that up to $3,000,000 will be allocated annually for DREAM Sentinels awards, subject to the availability of funds.

Upcoming Webinar: Building Research Capacity of New Faculty in Biology (BRC-BIO)

Please join the Building Research Capacity of New Faculty in Biology (BRC-BIO) program for a webinar on Tuesday, May 10th, 2021 from 3:00 PM – 4:00 PM EDT. There will be a short presentation, followed by an open Q&A session with cognizant Program Officers.

BRC-BIO is a new NSF program intended to enhance research capacity and broaden participation among new faculty of biology at minority-serving institutions (MSIs), predominantly undergraduate institutions (PUIs), and other universities and colleges that are not among the nation’s most research-intensive and resourced institutions.

Some key information from the solicitation:

  • Principal investigators must be at the Assistant Professor rank (or tenure-track equivalent) with service for no more than 3 years at their current institution by the submission date.
  • Proposed projects should help enable the establishment of research programs that will be competitive for future research proposals to the NSF (e.g., CAREER) or other agencies. Projects should enrich undergraduate research experiences and thereby grow the STEM workforce.
  • Projects can include biology-focused research collaborations among those in academia, or partnerships with industry or other non-academic partners that advance the PI’s research program. 
  • Next submission window:  June 01 – June 30, 2022

Please register in advance for the webinar below, and share this invitation with anyone you think may be interested:

https://nsf.zoomgov.com/webinar/register/WN_XRIhEdP9S4e9nYOsc1axpg

Click here for a recap of the previous webinars for the BRC-BIO program. If you have additional questions, please reach out to the BRC-BIO working group via email (BRC-BIO@nsf.gov).

MCB Congratulates its FY 2022 CAREER Awardees and Reminds the Community of the Upcoming CAREER Solicitation Deadline

MCB Congratulates its newest cohort of CAREER awardees.  The NSF Faculty Early CAREER Development Award (CAREER) is the most prestigious award that NSF gives to early career investigators, enabling these new faculty to embark on an academic career that integrates research and education. In Fiscal year 2022, MCB funded 33 CAREER awards to new faculty in 18 states, including 5 EPSCoR states, and at a diverse set of institutions, including those that are research intensive, primarily undergraduate, and minority-serving. 

Photo by Aphiwat Chuangchoem

The CAREER awards in the FY22 MCB portfolio covered topics across the entire spectrum of MCB-funded science from the molecular to cellular, including topics such as genome stability, DNA repair, intracellular signaling, and organelle formation. The projects used computational and experimental tools including those from biophysics and synthetic biology. Some exciting projects include:

  • The development of novel approaches to understand how proteins insert themselves into cellular membranes
  • How oxidative damage to DNA is repaired by cellular enzymes
  • How cells determined which duplicated genes were retained or lost during evolution
  • How components of bacterial immune systems can be utilized as tools for improving medicine or crop production.

A distinguishing criterion of CAREER awards is the integration of research with education, which is often described in the context of broader impacts.  Broader impacts efforts undertaken by this year’s awardees will engage high school students and their teachers, as well as community college, undergraduate and graduate students, in projects that range from course-based research experiences to activities involving inflatable project domes that can be transported across schools. In some of the most innovative activities, undergraduate students will test for water pollution by visually monitoring a biological motor, graduate students will use smartphone optical microscopes and microfluidic technologies to design devices for undergraduate classrooms, high school students will be introduced to synthetic biology through modular education kits, and STEM students will partner with journalism faculty to enhance their ability to effectively communicate science to the non-scientific community.

MCB was fortunate to have received support from the American Rescue Plan to enable the support of so many early career faculty.  

A complete listing of the new MCB CAREER award recipients can be found here (link).

How to Submit to the CAREER Program

The latest update of the CAREER solicitation (NSF 22-586) was recently released. 

Changes include:

  • Proposal submissions must be through Research.gov
  • There are new guidelines for letters from the Department Chair
  • Submission Deadline is Wednesday, July 27, 2022

Potential proposers are encouraged to read the full text of the solicitation. Submissions of CAREER proposals are encouraged from early-career faculty at all CAREER-eligible organizations and are especially encouraged from women, members of underrepresented minority groups, and persons with disabilities to apply.

Related upcoming events:

MCB is holding a Virtual Office Hour on May 11th, 2-3 p.m. EST about the Faculty Early Career Development Program (CAREER). You can register for the office hour here.


New Opportunity: Pathways to Enable Open-Source Ecosystems (POSE)

NSF has funded myriad research projects that resulted in publicly accessible, modifiable, and distributable open-source software, hardware, or data platforms. Now we are looking to support the development of these and other widely-used open-source products into open-source “ecosystems” (OSEs), each comprising a distributed community of developers and a broad base of users in academia, industry and government. Doing so will support thedevelopment of new technology solutions to problems of national, societal, and economic importance.

A new program, Pathways to Enable Open-Source Ecosystems (POSE), seeks to harness the power of open-source development to build these new technologies. The goal of the POSE program is to fund organizations to manage OSEs. OSEs based on hardware-, software- or data-based open-source products related to any NSF-supported field are encouraged.

Each OSE managing organization will be responsible for the creation and maintenance of infrastructure needed for efficient and secure operation of an OSE based around a specific open-source product or class of products. The early and intentional formation of such managing organizations is expected to ensure more secure open-source products, increased coordination of developer contributions, and a more focused route to impactful technologies.

Importantly, POSE is not intended to fund the development of open-source research products, including tools and artifacts or existing well-resourced OSEs or communities.

Program Phases
There are two phases of the POSE Program:

  • Phase I: OSE Scoping Proposals, budget to $300,000 for 1 year, 7-page max
    • Enables scoping activities to inform the development of the OSE. Should describe the long-term vision and impact of the proposed OSE, along with specific scoping activities that will lead to a well-developed and sustainable plan.
    • Proposal deadline: May 12, 2022
  • Phase II: OSE Development Grants, budget to $1,500,000 for 2 years, 15-page max
    • Supports transition of an open-source research product into a sustainable OSE. Should include a detailed project plan to support deployment of later-stage successful open-source products into operational environments; describe the current context; and articulate the long-term vision and impact of the proposed OSE.
    • Proposal deadline: October 21, 2022

For full details and submission information, please refer to the program solicitation, NSF 22-572.

Opportunities to Learn More
NSF Program Directors representing the POSE program will hold an informational webinar on March 23, 2022 from 3:30 PM ET to 4:30 PM ET.

Please register for the webinar here: https://nsf.zoomgov.com/webinar/register/WN_GDUveT2ZTBG4c-tNxaODoA.

NSF 101: Funding opportunities for minority-serving institutions (MSIs)

The NSF blog, Science Matters, recently posted about tips on how to find and apply for funding opportunities for minority serving institutions (MSIs). NSF has many programs designed to support researchers at MSIs and broaden participation of outstanding researchers from across a diverse group of regions, institutions and demographic groups.

The tips include:

  • how to find funding opportunities that specifically target faculty members, researchers and educators at MSIs using the NSF’s Funding Search tool;
  • how to double-check program eligibility;
  • and what to include in a “one-pager” when contacting a program officer in advance of proposal submission.

Read more on the Science Matters blog here.

FY2022 Future Manufacturing (FM) Solicitation Released

The Division of Molecular and Cellular Biosciences announces the release of a new solicitation for Future Manufacturing (NSF 22-568), the cross-directorate program supported by NSF’s Directorates for Engineering (ENG), Mathematical and Physical Sciences (MPS), Biological Sciences (BIO), Education and Human Resources (EHR), Computer and Information Science and Engineering (CISE), and Social, Behavioral, and Economic Sciences (SBE), as well as the Office of International Science and Engineering (OISE) and the Office of Integrative Activities (OIA).

Future Manufacturing promotes new manufacturing that will address urgent social challenges arising from climate change, global pandemics and health disparities, social and economic divides, infrastructure deficits of marginalized populations and communities, and environmental sustainability. Future Manufacturing complements existing efforts, supported by NSF and other federal agencies, in advanced manufacturing, but the focus of this program is to enable new, potentially transformative, manufacturing capabilities rather than incremental improvements over current manufacturing.

This funding opportunity supports fundamental research and education for a future workforce to overcome scientific, technological, educational, economic, and social barriers in order to catalyze new manufacturing capabilities that do not exist today, enhancing the U.S. leadership in manufacturing.

Submission and Review Information

Proposals must address one or more of the thrust areas, which for the FY 2022 solicitation are:

(1) Future Cyber Manufacturing Research

(2) Future Eco Manufacturing Research

(3) Future Biomanufacturing Research

This solicitation will support the following two award tracks:

Future Manufacturing Research Grants (FMRG) for up to four years; and

Future Manufacturing Seed Grants (FMSG) for up to two years.

The deadline for proposal submission is March 10, 2022. 

Proposals must be submitted through Research.gov or Grants.gov;

FastLane submissions will not be allowed.

NSF will review proposals according to the standard merit review criteria along with specific criteria that are detailed in the solicitation.  For full details on submission instructions, solicitation requirements, and contact information, see NSF ­­­22-568.

Opportunities to Learn More
An informational webinar will be held on February 25, 2022, from 1:00-2:00 PM EST to discuss the Future Manufacturing program and answer questions about this solicitation. Details on joining the webinar will be posted here.