Funding Opportunity

New DCL: Tool Development for Cell Biology (Tools4Cells)

A new Dear Colleague Letter (DCL) was issued by the Directorate for Biological Sciences (BIO) on the development of new tools and methods to advance our understanding of cells. Tool Development for Cell Biology, or Tools4Cells (NSF 21-057), seeks to expand our knowledge of cells using interdisciplinary approaches that can leverage advances in other fields and apply them to cell biology. Some examples of these advances include gene-editing technologies such as CRISPR/Cas9 applied to probe gene localization, and the application of cryo-EM and x-ray free electron lasers to the study of protein structure and dynamics.

Read more about the DCL criteria and proposal submission details here.

Informational EDGE Webinar: January 15, 2021, 2:00pm ET

The following is reposted from the IOS in Focus blog:

The Division of Integrative Organismal Systems (IOS), together with the Divisions of Biological Infrastructure (DBI), Environmental Biology (DEB), and Molecular and Cellular Biosciences (MCB) in the Directorate for Biological Sciences (BIO) at the National Science Foundation (NSF) and the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) will host a webinar about the Enabling Discovery through GEnomics (EDGE) program, which recently released a new solicitation, (NSF 21-546). Following a brief presentation, program directors from all of the Divisions and agencies will be available to answer questions from participants.

Through the EDGE program, the NSF and the NIH support genomic research that addresses the mechanistic basis of complex traits in diverse organisms within the context (environmental, developmental, social, and/or genomic) in which they function. The program also continues to support the development of innovative tools, technologies, resources, and infrastructure that advance biological research focused on the identification of the causal mechanisms connecting genes and phenotypes. 

Information on how to join the webinar live can be found below. The slides and transcript of the webinar will be posted here on the IOS blog as well as the EDGE program website after the live event.

All are welcome to join and ask questions!

Participant Instructions for the EDGE Program Webinar:

 When: Jan 15, 2021 02:00 PM Eastern Time (US and Canada) 
 Topic: EDGE Program Webinar
 
 Register in advance for this webinar:
 https://nsf.zoomgov.com/webinar/register/WN_G6jcpqjjRFCjcfSy0YbCxA
 
 Or an H.323/SIP room system:
     H.323: 161.199.138.10 (US West) or 161.199.136.10 (US East)
     Meeting ID: 161 766 4900
     Passcode: 468123
     SIP: 1617664900@sip.zoomgov.com  
     Passcode: 468123
 
After registering, you will receive a confirmation email containing information about joining the webinar.
 
If you require accessibility accommodations to participate in this webinar, send an email to ethiels@nsf.gov 14 days in advance of the webinar specifying the accommodations needed. 

Related NSF/BIO programs and Divisions
Neural Systems
Behavioral Systems
Developmental Systems
Plant Genome Research Program
Physiological and Structural Systems
Division of Biological Infrastructure
Division of Environmental Biology
Division of Molecular and Cellular Biosciences
  
Related NIH/NHGRI Divisions
Division of Genome Science
Division of Genomic Medicine
Division of Genomics and Society
  
Websites
Materials of the webinar will be available on the EDGE program website and the blogs of each of the Divisions in the Directorate for Biological Sciences following the webinar.

New Collaboration between NSF and the French Agence Nationale de la Recherche (ANR)

The National Science Foundation (NSF) has established an agreement on research cooperation with the French Agence Nationale de la Recherche (ANR). The Dear Colleague Letter, titled, “NSF/Physics/MCB Lead Agency Opportunity at the Physics – Molecular and Cellular Biosciences Interface” (NSF 20-120), encourages collaboration between the U.S. and French research communities.

Two NSF divisions – the Division of Molecular and Cellular Biosciences (MCB) and the Division of Physics (PHY) – are participating in this collaboration. Proposals must address the research priorities of each of the participating entities: ANR, MCB, and PHY. Proposals that use multidisciplinary approaches that emphasize quantitative, predictive and theory driven science aimed at understanding mechanisms underlying essential life processes at the molecular, subcellular and cellular scales are sought. Priority will be given to proposals that leverage unique resources and capabilities of partners in the U.S. and France.

A registration file (dossier) must be submitted by December 1, 2020. For full details on submission guidelines, program priorities, and contact information, see DCL NSF 20-120.

BIO Renews Collaboration with UKRI/BBSRC

a colorful abstract picture on a black background

The National Science Foundation’s Directorate for Biological Sciences (BIO) is renewing its collaboration with the UK Research and Innovation (UKRI) Biotechnology and Biological Sciences Research Council (BBSRC), described in Dear Colleague Letter (DCL) NSF 20-118.

Titled “UKRI/BBSRC-NSF/BIO Lead Agency Opportunity in Biological Informatics, Microbes and the Host Immune System, Quantum Biology and Synthetic Cell,” the DCL describes four new topical areas associated with the lead agency opportunity. The lead agency scheme allows for reciprocal acceptance of peer review through unsolicited mechanisms and helps reduce some of the current barriers to international collaborations.

There is a two-part application process: a letter of Intention to Submit (due October 21, 2020) will be reviewed for project eligibility. Eligible proposals will then be invited to submit to the appropriate lead agency program. Refer to the DCL for important details.

Projects must be a collaboration between at least one investigator in the US and one in the UK, must address the priorities of both UKRI/BBSRC and appropriate NSF/BIO divisions, and must address the topical areas identified in the DCL. Additionally, proposers must provide a clear rationale for the need for a US-UK collaboration, including the unique expertise and synergy that the collaborating groups will bring to the project.

For full details on submission guidelines, program priorities, and contact information, see DCL NSF 20-118. Please also see this NSF announcement about the collaboration.

Photo credit: agsandrew/Shutterstock.com

CAREER Webinar Scheduled in May

Learn more about the Faculty Early Career Development Program (CAREER) solicitation (NSF 20-525) in an upcoming webinar on May 13. The webinar will provide a briefing on the CAREER program and solicitation requirements along with a Q&A session. Read about significant changes to the solicitation in MCB’s previous blog post. Registration is required for the webinar, view details about registration here. Submit questions to careerwebinarqs@nsf.gov.

From The AD: New Funding Opportunities for Understanding the Rules of Life

Dear Colleagues,

BIO is excited to announce to the biological sciences community two new funding opportunities under the Understanding the Rules of Life (URoL) Big Idea: 1) Epigenetics and 2) Microbiome Theory and Mechanisms (MTM). The URoL Big Idea seeks to create a new paradigm at the convergence of science, engineering, and technology that will elucidate theoretical frameworks (rules) to enable prediction of the diversity of evolutionary solutions that biological systems use to support life processes seen across the planet. The National Science Foundation has recently invested $36 million in the first projects under the URoL portfolio from two separate solicitations and across more than thirty institutions.

The Epigenetics and MTM opportunities represent a collaboration across Directorates and Offices within the National Science Foundation. Specifically, Epigenetics intends to enable innovative research and promote multidisciplinary education and workforce training in the broad area of epigenetics, while MTM aims to understand and establish theory and mechanisms that govern the structure and function of microbiomes.

Integrative perspectives and research approaches from more than one research discipline are welcomed, as this is a cross-Directorate effort. The interdisciplinary scope of both programs aims to provide unique training and outreach opportunities to train the next generation of scientists in a diversity of scientific approaches and to engage society more generally.

Both programs offer two submission tracks:

  • Track 1 – for projects with a total budget of up to $500,000 and an award duration of up to 3 years, and
  • Track 2 – for projects with a total budget of up to $3,000,000 and award duration of up to 5 years.

For complete details on deadlines and submission guidelines, refer to the Epigenetics program website or contact the Epigenetics Team (epigen@nsf.gov), and the MTM program website or the MTM Team (microbiome@nsf.gov).

BIO looks forward to continuing working on this cross-Directorate venture.

Sincerely,

Image of the signature of Dr. Joanne Tornow, Assistant Director for Biological Sciences

Joanne Tornow, PhD
Assistant Director for Biological Sciences

Re-posted from Bio-Buzz

New solicitation – Semiconductor Synthetic Biology for Information Storage and Retrieval (NSF 20-518)

Funding is now available through the Semiconductor Synthetic Biology for Information Storage and Retrieval Technologies (SemiSynBio-II) solicitation (NSF 20-518) which seeks to leverage synthetic biology tools, concepts, and methodologies to advance the development of next-generation semiconductor information storage and retrieval technologies that are driven by biological principles and use biomaterials in the fabrication of storage and retrieval devices and systems.  

The goal of the SemiSynBio-II research program will be to foster high-risk/high-reward, multi-disciplinary, longer-term basic research leading to novel high-payoff solutions for the information-storage and retrieval industries based on recent progress in synthetic biology and the know-how of the semiconductor technology.

This program aims to seed and foster collaborations among the researchers in physics, chemistry, biology, materials science, computer science, and engineering disciplines to develop new cross-disciplinary projects and curricula that will model and integrate concepts, tools and methodology.

This solicitation builds from the previous SemiSynBio solicitation (NSF 17-557, no longer active) to include aspects of data retrieval. Proposals can be submitted during the submission window (due by 5 p.m. submitter’s local time): February 14, 2020 – March 16, 2020. Full program details including program priorities, submission guidelines, and contact information can be found in the full solicitation NSF 20-518.

Photo credit: SidorArt/Shutterstock.com

New Solicitation – Transitions to Excellence in Molecular and Cellular Biosciences Research (Transitions) (NSF 20-505)

Funding opportunities are now available for mid-career or later-stage researchers (Associate or Full Professor, or equivalent) to expand or make a transition in their research programs via a sabbatical leave or similar mechanism of professional development and then develop a new research program in their own lab based on the sabbatical leave experience.

Awards will fund up to six months of PI salary during the first sabbatical or professional development year, followed by support to continue the research program for two subsequent years upon the PI’s return to normal academic duties. Proposals are welcome in all areas currently funded by MCB, and proposals addressing major open questions at the intersections of biology with other disciplines, such as physics, chemistry, mathematics, computer sciences, and engineering are of particular interest to the program.

Proposals are accepted any time, in accordance with MCB’s no-deadline core solicitation. Program details, including more information on program priorities and additional criteria, can be found in the full solicitation (NSF 20-505).

Expanded Funding Opportunities for Collaborations between NSF BIO and UK Researchers

a colorful abstract picture on a black background

NSF BIO researchers can now submit collaborative proposals with British institutions in four new topic areas, Bioinformatics, Microbiome, Quantum Biology, and Synthetic Biology/Synthetic Cell. This opportunity to submit collaborative projects that are reviewed only once, either at NSF BIO or BBSRC, is highlighted in the Dear Colleague Letter (DCL) NSF 19-058, which explains the process for preparation of the letter of intent and proposal submission to this funding opportunity. 

There is a 2-stage application process: a letter of intent (due July 2, 2019) after which full proposals will be invited to their appropriate programs in both the UKRI/BBSRC (due 2nd October 2019) and NSF/BIO (full proposals accepted anytime).

Projects must be a collaboration between at least one investigator in the US and one in the UK and must address the priorities of both UKRI/BBSRC and appropriate NSF/BIO Divisions. Additionally, proposers must provide a clear rationale for the need for a US-UK collaboration, including the unique expertise and synergy that the collaborating groups will bring to the project.

For full details on submission guidelines, program priorities, and contact information see DCL NSF 19-058.

New Funding Opportunities: Rules of Life Solicitations

a picture of a hand dripping drops of water onto a small plant with dramatic sunlight in the backgroundThe National Science Foundation recently announced two new solicitations: Understanding the Rules of Life: Epigenetics (NSF 18-600), and Understanding the Rules of Life: Building a Synthetic Cell (NSF 18-599). These NSF-wide opportunities are part of Understanding the Rules of Life: Predicting Phenotype, one of NSF’s 10  “Big Ideas” for future investment.

 

A headline banner reading "Understanding the rules of life: epigenetics" underneath of which is a cartoon of a short strand of DNA wrapped around three histones like three beads on a single string

Understanding the Rules of Life: Epigenetics (NSF 18-600) invites proposals which investigate heritable biological or chemical mechanisms that produce a phenotypic effect without alteration of the DNA sequence.  Projects must integrate education perspectives and research approaches from more than one research discipline (e.g., biology, chemistry, computer science, engineering, geology, mathematics, physics, social and behavioral sciences).

Full proposals are due February 1, 2019 and can be submitted in one of two submission tracks:

(1) award duration of up to 3 years and a total budget of $500,000 or

(2) award duration of up to 5 years and a total budget of $3,000,000.

The specifics of the program priorities and areas of emphasis, as well as additional limitations and guidelines, can be found in the full solicitation.

 

A title banner reading "understanding the rules of life: building a synthetic cell" over an image of a plant root tip with each cell glowing green due to GFP attached to the cell wall

Understanding the Rules of life: Building a Synthetic Cell: An Ideas Lab Activity (NSF 18-599) invites researchers to apply to participate in an inter-disciplinary Ideas Lab focused on facilitating innovative research projects for designing, fabricating, and validating synthetic cells that express specified phenotypes. Up to $10,000,000 of funding is available for successful project proposals resulting from the Ideas Lab.

Building a synthetic cell is a grand challenge at the interface between biological, mathematical, computer and physical sciences and engineering.  Meeting this challenge requires simultaneous careful exploration of the social and ethical dimensions of such research as well as educating today’s students to engage in the activities and technologies required to develop and use synthetic cells.

To apply to this program, researchers should:

  • submit preliminary proposals due December 28, 2018,
  • participate, if selected, in the Ideas Lab workshop to be held February 25 – March 1, 2019, and
  • if invited to do so, submit, as part of a team, a full proposal due May 13, 2019.

Full details regarding the specifics of the research ideas, proposal limitations, and the application process can be found in the full solicitation.