Summary of MCB RAPID Awards

This post was updated on Monday, June 22, 2020.

The Division of Molecular and Cellular Biosciences funded 23 proposals (as of June 22) submitted in response to the Dear Colleague Letter on the Coronavirus Disease 2019 (COVID-19) (NSF 20-052) released March 4, 2020 (and now archived). The awards, made through the Rapid Response Research (RAPID) funding mechanism, support research focused on the characterization and modeling of coronavirus SARS-CoV-2, the virus that causes COVID-19. Read more about the RAPID funding mechanism in Chapter II.E.1 (Rapid Response Research) of the Proposal & Award Policies and Procedures Guide (PAPPG).

The proposed research projects will contribute to viral tracking and prevention efforts, provide information on viral transmission and biology of infection, and aid drug development for infection treatment and prevention. Links to these RAPID awards can be found in the table below. More information on funding made by the National Science Foundation to support research on the coronavirus may be found here.

Proposal IDProposal TitlePI Name
2027070RAPID: Revealing the intermolecular interactions between the SARS-CoV-2/COVID-19 fusion peptide and the host cell membrane that underlie its flexibility in host tropismDaniel, Susan
2027096RAPID: Biophysical characterization of the native SARS-CoV-2 virion by atomistic simulationsPerilla, Juan
2027169RAPID: Development of Rapid Point of Care SARS-CoV-2 Detection SystemEllington, Andrew D.
2027291RAPID:  Multiscale Modeling Of SARS-CoV-2 Viral Intracellular and Intercellular DynamicsSrivastava, Ranjan
2027611RAPID: Factors Contributing To Sequence Conservation in the SARS-CoV-2 GenomeGrigoriev, Andrey
2028443RAPID: Computational studies of the structural dynamics, function and inhibition of the SARS-CoV-2 coronavirus spike proteinAndricioaei, Ioan
2028651RAPID: Point-of-Need Detection of COVID-19 using CRISPR-Enabled Cell-Free Synthetic BiologyLucks, Julius
2028935RAPID: Impact of inhibitors on SARS-CoV-2 polymerase and fidelity control of RNA synthesisYu, Jin
2029105RAPID: A multiscale approach to dissect SARS-CoV-2 attachment to host cells and detect viruses on surfacesVahey, Michael D.
2029281RAPID: Ecological Dynamics of Human CoronavirusYin, John
2030080RAPID: Exosomal tRNA fragments may constitute an innate viral defense against SARS-CoV-2 and other respiratory RNA viruses.Borchert, Glen M.
2030473RAPID: Structure of Membrane-Bound Fusion Peptide of SARS-CoV-2 Required for InfectionVan Doren, Steven R.
2031068RAPID: Determination of SARS-CoV-2 Spike Glycoprotein Palmitoylation and its Contribution to Virus-Cell Fusion and Surface Protein-Protein InteractionsDevaraj, Neal
2031094RAPID: Host-pathogen interactions during genome replication of SARS-CoV2Ha, Taekjip
2031762Collaborative Research: RAPID: Molecular underpinnings that define volatile compound signature of the lungBushan, Abhinav
2032054RAPID: Understanding the Effects of Glycosylation on Spike Vulnerabilities and the Host Range of SARS-CoV-2Amaro, Rommie E.
2032310RAPID: Biomimicry of SARS-CoV-2 and its consequences for infectivity and inflammationWong, Gerard
2032518RAPID: Membrane remodeling dynamics by SARS-CoV-2Serra-Moreno, Ruth
2032861RAPID: What is the role of extracellular vimentin in SARS2 host cell entry?Patteson, Alison
2033354RAPID: Impact of SARS-CoV2 on function of the cellular tRNA methyltransferase 1 and redox homeostasisFu, Dragony
2033695RAPID: Building a visual consensus model of the SARS-CoV-2 life cycleIwasa, Janet
2033939RAPID: Molecular Insights into the SARS-CoV-2 Spike Protein Activation via a Novel Interaction with a Human Cell Surface Target ProteinIzard, Tina
2035558RAPID: Mechanisms of Polymerization Catalyzed by the SARS-CoV-2 RNA Dependent RNA PolymeraseLucius, Aaron

MCB anticipates several more RAPID awards this fiscal year.