The Division of Molecular and Cellular Biosciences (MCB) joins the National Science Foundation (NSF), and the scientific community in congratulating Dr. Jennifer Doudna and Dr. Emmanuelle Charpentier on their 2020 Nobel Prize in Chemistry. The two were awarded the prize jointly “for the development of a method for genome editing.” A little over a decade ago, MCB awarded Dr. Doudna the first in a series of grants to explore Mechanisms of Acquired Immunity in Bacteria (MCB 1244557). “It is wonderful to see the fruits of Dr. Doudna’s work, initially enabled by NSF investment in discovery-driven research, which is reaping many societal benefits” said Dr. Basil Nikolau, MCB Division Director.
“CRISPR-Cas9 is opening new worlds of possibility in fields as wide-ranging as bioengineering, medicine, agriculture, and biomanufacturing. Researchers are still working to understand the full potential of this important tool,” said National Science Foundation Director Sethuraman Panchanathan. “The teams behind this groundbreaking discovery have uncovered and developed fundamental science that will result in decades’ worth of applications. NSF has long supported the discovery-driven research of Dr. Jennifer Doudna and her lab with grants, including our prestigious Alan T. Waterman award. We congratulate her and Emmanuelle Charpentier and join the rest of the world in waiting to see what CRISPR produces next,” said Dr. Panchanathan in a news release.
© Nobel Media. Ill. N. Elmehed
MCB joins the rest of the scientific community in congratulating NSF funded researcher Joachim Frank who, along with Jaques Dubochet, and Richard Henderson, was awarded the Nobel Prize in Chemistry for his role in the development of Cryo-electron microscopy (Cryo-EM).
“Cryo-electron microscopy fundamentally changed biology and biochemistry, allowing scientists to create 3-D reconstructions of the biomolecular processes that support life,” said NSF Director France Córdova. “The technology delivers an unprecedented look at life at the atomic scale, providing us with accurate models of everything from viruses to antibodies. Joachim Frank demonstrated that potential to NSF in 1984, when the agency helped him acquire a high-resolution electron microscope for 3-D reconstruction, and then continued to support his development of new applications for the technology over the following decades. Biochemistry owes Frank and this year’s other two Chemistry laureates, Richard Henderson and Jacques Dubochet, a debt for this important visualization tool.”
Dr. Engin Serpersu, Program Director and Molecular Biophysics Cluster Leader stated that “technological developments and improvements in data analysis transformed Cryo-EM from being suitable only to study global structural properties of biological complexes to providing 3D structures with atomic level resolution. These developments also allow researchers to examine proteins smaller than we ever imagined possible, including ones as small as 100 kDa. Undoubtedly, Cryo-EM is now one of the mainstay structural tools helping scientists in a broad range of biological problems and its development is well worth this honor.”
Congratulations to Dr. Aziz Sancar on being awarded a 2015 Nobel Prize in Chemistry! Dr. Sancar is one of three recipients of this award whose research on “mechanistic studies of DNA repair” has brought forth new information on how cells repair DNA after being damaged by ultraviolet radiation, free radical molecules, and other carcinogenic substances. Professor Sancar received the NSF Presidential Young Investigator Award (PYI) from MCB at the beginning of his academic career for the project entitled “Characterization of UvrABC Excision Nuclease of E. coli”, supported from 1983 to 1989.
MCB proudly recognizes the early investments made into Dr. Sancar and his research as his work has made profound impacts on the progress of science.
Please click here for a link to a transcript of the phone interview with Dr. Sancar immediately following the announcement of the 2015 Nobel Prize in Chemistry.